Maine Coons are known as "gentle giants." They possess above-average intelligence, making them relatively easy to train. They are known for being loyal to their family and cautious (but not aggressive) around strangers, but they can also be quite independent. They are playful throughout their lives, with males tending to be more clownish and females generally displaying more dignity. Still, both males and females are about equally affectionate.

Many Maine Coons are fascinated by water. Some zoologists theorize that this personality trait comes from their ancestors, who were aboard ships for much of their lives. Maine Coons are also well known for being very vocal. They are known for frequent yowling, chattering, chirping, "talking" (especially "talking back" to their owners), and other loud vocalizations. Maine Coons can make a pleasant and lively addition to any family.